Hema.to

Seconds from raw cytometry data to sound decisions

AI-powered cytometry analysis from data to report with CellStudio (RUO).

One workflow from cytometer to final report.

  1. Cytometry data uploads automatically

    CellStudio Connect automatically picks up FCS/LMD files from your flow cytometer and uploads them to the hema.to cloud, fully anonymized.

    Flow cytometer

    Measures FCS/LMD data

    CellStudio Connect

    Anonymizes and uploads the data

    Laboratory

    hema.to cloud

    Stores and analyzes data

    hema.to
  2. AI classifies every cell

    All basic cell types are automatically classified, independent of panel, SOP or device, using AI trained on hema.to’s large database with many different panels.

    CellStudio case with AI-classified cell plots shown in color
    CellStudio case with unclassified grayscale cell plots
    BeforeAfter
  3. You review the case

    You stay in control and can inspect, amend and modify algorithmic classifications in CellStudio (RUO). Changes you make will be reflected in the cytograms, phenotypes and the created reports.

  4. A print-ready report is generated in one click

    Text, CSV or PDF? A report with your results is generated with one click, configured to your unique reporting requirements.

Automated cell annotations for every case.

  • Correlation plots comparing CellStudio's AI model with laboratory cell population counts

    Tailor-made model for your data

    We use cases from your lab and combine them with hema.to’s large, internal reference database to create an AI model fine-tuned to your panels and data.

    Correlation plots comparing CellStudio's AI model with laboratory cell population counts
  • CellStudio analysis showing AI-classified cell populations and a color-coded cytogram

    AI cell classification

    CellStudio’s single-cell classifier identifies every cell in a case and assigns it a cell type. Automated clustering can optionally be applied for supported cell types.

    See cell ontology

    CellStudio analysis showing AI-classified cell populations and a color-coded cytogram
  • AI-assisted quality remarks reporting minor fluidics, lysis, and cut population issues

    Automated quality checks

    When analyzing a case, we automatically assess for sample degradation, cut cell populations, and potential fluidics or lysis issues.

    AI-assisted quality remarks reporting minor fluidics, lysis, and cut population issues
  • Cell population tree highlighting NKT cells identified by a CD56-positive phenotype

    Phenotype-based subsets

    You can configure subsets based on a cell type and phenotype that will be automatically identified and added to your cell tree.

    Cell population tree highlighting NKT cells identified by a CD56-positive phenotype
  • CellStudio case labels with details of a phenotype-based rule for possible DLBCL CD10+

    Workflow rules

    Cases can be automatically assigned labels based on cell population and phenotype criteria. Hema.to comes with a full WHO-based catalogue of rules that can be added to your app with one click.

    CellStudio case labels with details of a phenotype-based rule for possible DLBCL CD10+
  • CellStudio analysis showing kappa and lambda clonality cytograms for several B-cell populations

    Clonality labels

    Kappa and lambda clonality is automatically assessed for B cells and their subpopulations. Detailed clonality statistics are available on a population level and can be referenced in reports.

    CellStudio analysis showing kappa and lambda clonality cytograms for several B-cell populations

Advanced cytometry tools when you need them.

  • Seamless editing

    CellStudio features a rich, intuitive suite of annotation tools for flow cytometry data that scales to millions of events per tube.

  • CellStudio cytogram with adjustable phenotype thresholds and a table of marker expression statistics

    Fine-grained phenotypes

    Define a target population and see its detailed phenotype and statistics. Watch it update in real time when making edits to the data with CellStudio’s lasso and threshold tools.

    CellStudio cytogram with adjustable phenotype thresholds and a table of marker expression statistics
  • CellStudio case analysis shown in light and dark themes with customized population colors

    Customizable color palette

    CellStudio is available in both a light and dark theme. You can customize the color of every cell population for either mode in your user settings.

    CellStudio case analysis shown in light and dark themes with customized population colors
  • Flexible cytograms

    Cytograms can display data in linear, log and symlog scale. Axis parameters can be reconfigured seamlessly while analyzing a case.

  • CellStudio compensation editor showing a matrix alongside a grid of color-coded cytograms

    Adjustable compensation

    CellStudio features a visual editor for the case’s compensation matrix. Once changed, the AI analysis can be rerun with the updated parameters with one click.

    CellStudio compensation editor showing a matrix alongside a grid of color-coded cytograms
  • CellStudio merged tube view showing aligned cell populations across four cytograms

    Merged tube view

    Quickly align clusters across tubes with CellStudio’s merged tube view. Merging is available for all cell populations and remembers your settings the next time you open a case with the same panel.

    CellStudio merged tube view showing aligned cell populations across four cytograms

Manage every case from start to finish.

  • CellStudio tube settings mapping flow cytometry parameters, fluorochromes, and markers

    Deep panel configuration

    Configure a template for your panels once and have CellStudio automatically apply marker mappings and cytogram layouts to all cases.

    CellStudio tube settings mapping flow cytometry parameters, fluorochromes, and markers
  • CellStudio report builder previewing a leukocyte differentiation report with cell counts and findings

    Print-ready reports

    Define your reporting template for a panel or material once and have CellStudio create print-ready PDF reports with one click. CellStudio’s reports contain both free-form text as well as a detailed cell statistics section.

    CellStudio report builder previewing a leukocyte differentiation report with cell counts and findings
  • CellStudio dashboard listing cases with their status, priority, assignee, alarms, and tubes

    Dashboard overview

    See and manage your team’s worklist in one central place.

    CellStudio dashboard listing cases with their status, priority, assignee, alarms, and tubes
  • Case header showing reporting status, high priority, and assignment to a user

    Case priority & assignment

    Track which cases are important and who is working on them with case priorities and assignments. Filter the dashboard to see your most important to-dos.

    Case header showing reporting status, high priority, and assignment to a user
  • CellStudio review dialog with a comment and controls to reject or approve a case analysis

    Four-eyes principle reviews

    CellStudio can be configured to enforce review steps for annotations and reports to implement four-eyes principle quality controls.

    CellStudio review dialog with a comment and controls to reject or approve a case analysis

Ready for your routine.

Validation scope

  • Consistent across panels and specimen types

    Peripheral blood and bone marrow

  • Expert-level leukocyte differentiation

  • Validated in pathological and non-pathological cases

Read the HPH study

Study at a glance

  • 5 laboratory sites
  • 20,000 patient samples
  • Routine FACS panels
  • Automated AI analysis

What this means for your lab

  • Reproducible cell identification
  • Panel-independent consistency
  • Reduced operator variability

hema.to by the numbers.

Hema.to
Analyses supported by hema.to
4,000+
FCS files in our database
600,000+
Mean accuracy in our prospective interventional clinical study
98.6%
Peer-reviewed publications
4

What our customers and partners say.

I am very excited about implementing the decision support system developed by hema.to into the flow cytometry lab space! It will help streamline and automate analysis workflows leading to improved accuracy and turnaround times.”

Prof. Dr. Pozdnyakova

Director of hematopathology at UPenn Medicine

Partners

Investors

Let's talk about making your cytometry fast, reproducible and flexible.